Virus Chemical Modification Services
Creative BioMart Vir-Sci is one of the well-recognized experts who is professional in chemical modification of viral vectors. Virus chemical modification is a great help for gene therapy. We have years of virus chemical modification experience and advanced technology and equipment to provide fast and satisfactory virus chemical modification services according to customer needs.
Virus Chemical Modification
Viruses are vectors that are commonly used in gene therapy, but they still cannot deliver therapeutic genes efficiently and selectively to specific target cells. Therefore, it is necessary to construct a viral vector with high transduction efficiency, strong selectivity and low immunogenicity as a tool for gene therapy. Virus chemical modification includes covalent and non-covalent modification. For covalent modification, the natural amino acids or post-modified non-natural amino acid residues of viral proteins are used to directly covalently couple viral vectors, which is a direct, stable and effective modification method. Using chemical modification techniques of viruses to couple various modified molecules to viral vectors can overcome some of the defects of the virus and enhance the clinical applicability of the virus. In addition, the viral vectors can also be chemically modified using electrostatic effects, hydrophobic effects, metal chelation, biological affinity, etc. The chemical modification method of the virus is a cross-technical means of chemistry and biology, which can be used to solve the bottleneck problem of gene therapy and promote the development of gene therapy to a safer and more efficient direction.
Figure 1. Traditional bioconjugation methods used for covalent modification of virus particles (Strable, et al. 2009)
Our Virus chemical modification Services
- Amino Acids Incorporation Service
- Protein/Polymer Hybrid Conjugates Service
- Supramolecular Chemistry Service
Our virus chemical modification platform can provide customers with a variety of amino acids incorporation services, including lysine incorporation, cysteine incorporation, and arginine incorporation services. Our experienced technical team can provide customers with better quality amino acid incorporation services suitable for a variety of viral vectors.
Protein-polymer hybrid conjugates are a combination of proteins and polymers that have both the biological activity of proteins and the chemical and physical properties of polymers. They are widely used in biomedical fields, such as drug/biomacromolecule delivery systems. The protein/polymer hybrid conjugates service we provide is suitable for a variety of polymers, and our efficient, high-quality and personalized protein/polymer hybrid conjugates service can meet customer needs in all aspects.
Viruses belong to natural supramolecular building blocks, and supramolecular interactions, such as metal ion coordination bonds, hydrogen bonds, π-π stacking effect, electrostatic effect and hydrophobic effect, are useful tools for the construction of supramolecular compounds with specific structures and functions, which can be used for the construction and performance improvement of supramolecular polymers. Creative BioMart Vrius provides customers with efficient and high-quality supramolecular chemistry services.
Our Advantages
- Ensure high efficiency and quality for virus chemical modification services
- Competitive price in the market of virus chemical modification services
- Ensure 24/7 online service
Workflow of Virus Services at Creative BioMart Vir-Sci
Creative BioMart Vir-Sci has an expert team that own extensive experience in the field of virus chemical modification, involving various viruses and technical methods. We guarantee that each specific experimental step in the chemical modification process is strictly controlled to ensure high quality of virus chemical modification services. If you are seeking for related services, please feel free to contact us, our expert team will design high-quality virus chemical modification solutions according to your needs and provide you with professional and thoughtful services.
References
- Sabine, B.; et al. Optimizing targeted gene delivery: chemical modification of viral vectors and synthesis of artificial virus vector systems. AAPS Journal, 2011, 8(4): E731-E742.
- Strable, E., Finn, M.G. Chemical Modification of Viruses and Virus-Like Particles. In: Manchester M., Steinmetz N.F. (eds) Viruses and Nanotechnology. Current Topics in Microbiology and Immunology. 2009, vol 327. Springer, Berlin, Heidelberg.
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