Other Vectors Service
For cell types that are not suitable for lipid-mediated transfection, viral vectors are often used. The clinical research related virus vector services provided by Creative BioMart Vir-Sci mainly include lentiviral vector service, adenovirus vector service, herpes simplex virus vectorservice, vaccinia viral vector service, adeno-associated virus vector service and baculovirus vector service. In addition, the virus vectors described below can also be provided.
Foamy Virus Vector
Foam virus (FV) is a unique retrovirus belonging to the genus spumavirus. FV vectors are effective gene delivery vectors, including prototype foam virus (PFV), simian foam virus type 1 (SFV-1), and feline foam virus (FFV). Here, Creative BioMart Vir-Sci offers second- and third-generation FV vectors with high titer-free FV vector formulations to evaluate transduction.
Hybrid Vector
Hybrid vectors are vector viruses that have been engineered to have more than one vector quality. Modify the virus to avoid the disadvantages of typical viral vectors, which may have limited load capacity, immunogenicity, genetic toxicity, and cannot support adequate transgene expression in the long term. By replacing undesired elements with desired capabilities, hybrid vectors may be superior to standard transfection vectors in the future in terms of safety and therapeutic efficiency.
Figure 1. Hybrid vector. (Müther, Nadine.; et al. 2009）
Poxvirus Vector
Poxvirus vectors are one of the most commonly used viral vectors for developing preventive and therapeutic cancer vaccines against infectious diseases. These vectors are usually attenuated or engineered to safely deliver genes encoding different pathogen antigens. Creative BioMart Vir-Sci has produced and purified poxvirus vectors on a large scale through mature cell culture technologies to meet the needs of various applications, thereby greatly promoting the development of new vaccine vectors.
Our Viral Vector Services
Creative BioMart Vir-Sci provides global integrated solutions for viral vector production, including:
- Process transfer, development, optimization, scale-up and verification.
- Analysis transfer, development and verification.
- Manufacturing from small to large.
- Upstream, downstream and aseptic filling.
- Preclinical and commercial applications.
Applications
- Transgene delivery.
- Optical imaging and deep tissue imaging.
- Preclinical research and drug development.
- Act as a powerful tool in disease studies.
Workflow of Services at Creative BioMart Vir-Sci
Creative BioMart Vir-Sci has a team of experts and has extensive experience in the field of viral vector services, involving various viruses and technical methods. Creative BioMart Vir-Sci, as a reliable team, is committed to supporting your preclinical and commercial production of viral vectors and is proud of it. If you need related services, please feel free to contact us, our expert team will design specific virus vector services according to your needs, and provide you with professional and thoughtful services.
References
- Lundstrom, K. Viral Vectors in Gene Therapy. Diseases, 2018, 6(2): 42.
- Müther, N.; et al. Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution. Viruses, 2009, 1(3):1295-1324.