Gene Delivery Systems Service
Creative BioMart Vir-Sci is one of the recognized experts, which is a professional in the gene delivery system. We have many years of experience in gene delivery systems and can provide fast and satisfactory gene delivery systems according to customer needs.
Viral Vector Delivery
Gene delivery is the introduction of genes into cells, and these cells then produce the required therapeutic substances, mainly protein products. For viral delivery, foreign genes are attached to the virions that have been modified to remove harmful parts and introduced into cells to achieve gene transmission. All viruses can be developed into a tool for gene transmission through a series of processes, such as deleting genes related to carcinogenesis, toxicity and replication, and inserting foreign therapeutic genes at appropriate locations. However, due to the wide differences in the life cycle and molecular pathology of different viruses, four types of viral vectors are mainly used: retroviral vectors (including lentiviral vectors), adenovirus vectors, adeno-associated virus vectors, and simple herpesvirus vector.
Figure 1. Gene therapy trials since 2000. (Gray, S. J., et al. 2010.)
Gene Delivery Method
The delivery of genes to host cells involves the following two steps:
- Delete some of the essential genes of the virus, and replace the non-essential genes of the virus with the foreign genes (target genes) (the non-coding region remains unchanged)
- Recombinant vector plasmid
The foreign gene, cis-acting element and plasmid backbone are packaged into the viral capsid under the action of an auxiliary system (trans-acting element) to form a recombinant vector plasmid.
Viral Vectors Currently Available
Retrovirus, adenovirus, adeno-associated virus, herpes virus, alphavirus.
Applications
In recent years, substantial advances have been made in the development of technologies that allow specific cells to be targeted for several types of vectors, especially viral vectors. These vectors have been used in 70% of gene therapy clinical trials. Specific viruses were selected as gene delivery vehicles because of their ability to carry foreign genes and the ability to effectively deliver these genes in relation to effective gene expression.
Our Services for Gene Delivery Systems
- Lentiviral Vector Service
- Adenovirus Vector Service
- Herpes Simplex Virus Vector Service
- Vaccinia Viral Vector Service
- Adeno-Associated Virus Vector Service
- Baculovirus Vector Service
- Other Virus Vectors Service
Our Advantage
- Mature and reliable gene delivery platform, rich project experience.
- Based on accurate data analysis, analysis content and pre-research and verification methods to provide you with high-quality services mature and feasible.
Workflow of Microbiology Services at Creative BioMart Vir-Sci
Creative BioMart Vir-Sci has extensive experience in the field of gene delivery systems. We guarantee strict control of each experimental step, you can choose the appropriate viral vector according to your needs. If you are looking for related services, please feel free to contact us, our expert team will design high-quality gene delivery system according to your needs, and provide you with professional and thoughtful services.
References
- Jones C.H., et al. Overcoming nonviral gene delivery barriers: perspective and future. Molecular Pharmaceutics. 2013, 10 (11): 4082–98.
- Gray, S. J.; et al. Viral vectors and delivery strategies for CNS gene therapy. Therapeutic Delivery. 2010, 1(4): 517–534.
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