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Supramolecular Chemistry Service

Creative BioMart Vir-Sci is a recognized expert in supramolecular chemistry service. We have a mature supramolecular chemistry service platform that can provide rapid and satisfactory supramolecular chemistry service according to customer needs. In addition, we also provide amino acids incorporation service and protein/polymer hybrid conjugates service.

Introduction

Viruses are natural supramolecular building blocks. Virus capsids are composed of multiple copies of coat proteins. They are assembled into structures of different sizes and shapes, showing complex functions. Supramolecular usually refer to the combination of two or more molecules that rely on intermolecular interactions to form complex, organized aggregates, and maintain certain integrity to have a clear microstructure and macroscopic properties. The concept of supramolecular chemistry was first proposed by the French scientist JM Lehn in 1987, when he pointed out that the molecular chemistry is based on covalent bonds, and supramolecular chemistry is based on molecular assemblies and intermolecular bonds. Supramolecular chemistry is the chemistry of molecular aggregates based on the interaction of non-covalent bonds between molecules. In other words, the interaction between molecules is the core of supramolecular chemistry.

Supramolecular Interactions in Supramolecular Chemistry

In supramolecular chemistry, different types of intermolecular interactions can be distinguished. According to their different strength, orientation, and dependence on distance and angle, they can be divided into metal ion coordination bonds, hydrogen bonds, π-π stacking effect, electrostatic effect and hydrophobic effect. These forces have become the basic method for driving supramolecular self-assembly. According to the principle of supramolecular self-assembly, we can use the interaction force between molecules as a tool to assemble components or building modules with specific structures and functions into new supramolecular compounds in a certain way. These new compounds can not only show the unique properties not possessed by a single molecule, but also greatly increase the types and number of compounds. If we can control the process of supramolecular self-assembly, we can obtain compounds with specific structures and functions more simply and reliably according to our intended goals.

The cowpea chlorotic mottle virus Fig 1. The cowpea chlorotic mottle virus (Pieters, et al. 2016)

Supramolecular Chemistry Application

Supramolecular polymers are special polymers that are formed by non-covalent interactions between monomer molecules (including hydrogen bonding, π-π interactions, metal coordination, etc.) and exhibit polymer properties in solution. Because non-covalent bonds are weakly interacting and have dynamic reversibility, supramolecular polymers also display many interesting functions (such as stimuli responsiveness, dynamic reversibility), making this type of dynamic assembly system unmatched by conventional polymers advantage. Among them, the hydrogen bond has the advantages of directionality, strong binding force, rich formation form, dynamic reversibility and predictable recognition performance, and is widely used in the construction and performance improvement of supramolecular polymers.

Our Advantages

  • Ensure high efficiency and quality for supramolecular chemistry services
  • Competitive price in the market of supramolecular chemistry services
  • Short service cycle
  • Ensure 24/7 online service

Workflow of Microbiology Services at Creative BioMart Vir-Sci

workflow

Creative BioMart Vir-Sci has an expert team that own extensive experience in the field of supramolecular chemistry, involving various technical methods. We guarantee that each specific experimental step in the supramolecular chemistry process is strictly controlled to ensure the provision of high-quality supramolecular chemistry service. If you are seeking for related services, please feel free to contact us, our expert team will design suitable technical solutions according to your needs, and provide you with professional and thoughtful services.

References

  1. Hofmeier, H.; et al. Combination of orthogonal supramolecular interactions in polymeric architectures. Chemical Communications. 2005, 19: 2423-2432.
  2. Pieters, B.J.G.E.; et al. Natural supramolecular protein assemblies. Chemical Society Reviews. 2016, 45: 24-39.

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